首都医学科学创新中心[Chinese Institutes for Medical Research (CIMR), Beijing]（简称创新中心）是北京市新成立的具有独立法人资格的新型研发机构。创新中心以推动医学科学发展、改善人类健康为目标，开展生物医学研究，致力于提升医学科学创新与成果转化能力，提高疾病诊断和治疗水平。我们将汇聚世界高水平科学家，与首都医学教育和科学研究优质资源紧密合作，打造多学科交叉融合的科研平台，综合自由探索、医学目标导向、有组织科研等途径，实践新型科研模式和体制机制，培养适应医学科学创新发展的优秀人才，逐步推进医教研产的深度融合。

实验室介绍

尤忠胜教授分别在浙江大学、中科院上海生化所、美国加州大学圣地亚哥分校（University of California, San Diego）生物系取得学士、硕士、博士学位，在索尔克生物研究所（Salk Institute）从事博士后研究。2009年成为美国圣路易斯华盛顿大学医学院（Washington University in St. Louis, School of Medicine, WashU Medicine）细胞生物学与生理学系助理教授，2023年晋升为正教授。尤忠胜实验室主要研究细胞基因组维持、RNA质量监测以及先天免疫机制，开发针对肿瘤、自身免疫等疾病的新型治疗策略和药物。在Nature Medicine, Molecular Cell, Nature Cell Biology等刊物发表多篇高水平论文，报道原创性发现。本实验室为不同学术背景的研究者提供开放的平台，诚邀有志之士与我们共赴探索、创新之旅。尤忠胜教授具有丰富的学生和博后培养经验，曾任WashU分子细胞博士生培养项目（MCB Graduate Program）联合主任、生物与生物医学部（Division of Biology and Biomedical Sciences）执行委员会委员。

实验室研究方向

1.基因组稳定性、RNA质量监测缺陷与先天免疫系统的相互作用；

2.离子和离子通道蛋白在cGAS/STING介导的先天免疫反应中的调控作用；

3.靶向TRPV2-STING互作，开发用于肿瘤与自身免疫疾病的精准治疗策略；

4.剪接体突变相关肿瘤中的NMD通路失调与靶向治疗前景。

近期主要研究成果

1.全新基因组保护信号通路：发现并解析一条由胞质DNA激活、 Ca²⁺介导的复制叉保护通路，鉴定了10余个核心调控因子(Li et al., Mol Cell2019; Li et al., Mol Cell2023; Kong et al., Nat Commun 2024)

2.TRPV2-STING互作: 首次发现STING与钙离子通道蛋白TRPV2在内质网上的相互作用，该互作调控细胞内钙离子水平，并控制cGAS/STING先天免疫系统的静息与激活（Li et al.,Mol Cell 2023; Cheng et al.,Cell Rep, accepted）

3.无义RNA降解调控与肿瘤治疗：构建多个NMD报告系统，用于高通量药物筛选与全基因组CRISPR遗传筛选，鉴定多个NMD抑制剂及调控因子；揭示NMD是携带剪接体突变的血液肿瘤的潜在治疗靶点 (Nickless et al., Nat Med2014; Nickless et al., JBC 2017; Cheruiyot et al., Cancer Res 2021)

代表性文章

Nature Communications, 2024, doi: 10.1038/s41467-024-48988-6. PMID: 38816425.

Molecular Cell, 2023, doi: 10.1016/j.molcel.2022.12.034. PMID: 36696898.

Molecular Cell, 2019, doi: 10.1016/j.molcel.2019.04.003. PMID: 31053472.

Cancer Research, 2021, doi: 10.1158/0008-5472.CAN-20-4016. PMID: 34215620.

Nature Medicine, 2014, doi: 10.1038/nm.3620. PMID: 25064126.

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副研究员（1-2名）

助理研究员（1-2名）

一、主要职责

1.在PI指导下独立开展研究工作；

2.协助PI指导研究生，撰写研究论文和项目申请。

二、任职要求

1.具有细胞生物学、生物信息学、结构生物学或其他相关领域的研究背景，3年或以上博后经历；

2.以第一作者身份在领域内主流期刊上发表过研究论文；

3.具备独立开展科研工作和指导研究生能力；

4.具有高涨的科研热情、严谨的科研态度、良好的沟通能力和团队合作精神；

5.具备良好的英语读写和交流能力，能够使用英文撰写论文。

博士后（2-3名）

一、主要职责

1.在PI指导下独立开展研究工作；

2.协助指导研究生以及撰写论文和基金申请。

二、任职要求

1.已获得或即将获得博士学位，具有细胞生物学、结构生物学、生物信息学或其他相关领域的研究背景；

2.以第一作者身份在领域内主流期刊上发表过或即将发表研究论文；

3.具备独立开展科研工作能力；

4.具有高涨的科研热情、严谨的科研态度、良好的沟通能力和团队合作精神；

5.具备良好的英语读写和日常交流能力，能够使用英文撰写论文。

科研助理（1-2名）

一、主要职责

1.独立或协助团队开展课题研究；

2.协助实验室运行管理。

二、任职要求

1.大学本科学历及以上，分子生物学、细胞生物学、生物化学或其它相关专业；

2.掌握分子生物学基本原理及操作能力，有细胞生物学、小鼠模型等研究经历优先；

3.诚实严谨，具备良好的沟通能力和团队协作能力；

4.具备良好的英语读写和日常交流能力。

福利待遇

1.根据应聘者的工作经验和能力，提供具有市场竞争力的薪酬（详情面谈）；

2.享受五险一金、带薪年假、体检和补充医疗保险等；

3.支持个人职业发展，提供必要的工作相关专业培训。

申请方法

应聘者请将个人简历、研究兴趣或计划，2-3名推荐人的姓名及联系方式，以及其他能证明科研能力的相关电子文件发送到邮箱zyou@cimrbj.ac.cn，邮件主题请注明“应聘者名字+具体应聘职位+硕博英才网”。

联系人：尤忠胜教授

联系地址：北京市丰台区右安门外西头条10号-首都医学科学创新中心

本招聘长期有效，至招聘到合适人选为止。

另外本实验室欢迎有对细胞生物学、生物信息学感兴趣的各阶段实习生、联培生前来学习交流。

ABOUT CIMR

Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research. CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment. For more information, please visit our website: www.cimrbj.ac.cn

Laboratory Introduction

Dr. You is currently an Investigator at CIMR and Associate Director of the Chinese Institute for Cancer Research within CIMR. Prior to joining CIMR in 2025, he was a tenured professor at Washington University in St. Louis, School of Medicine. The You lab at CIMR investigates the molecular mechanisms of genome maintenance, RNA surveillance, and innate immunity, with the overarching goal of advancing cancer and autoimmune disease treatment. We integrate cell biology, structural biology, drug screening, and animal models to drive these studies.  

Major Research Projects

The laboratory focuses on the following key research areas:

a. Intersection of DNA/RNA surveillance with innate immunity

b. Emerging roles of ions and ion channels in regulating cGAS/STING innate immune signaling

c. Therapeutic targeting of the TRPV2-STING axis in cancer and autoimmunity

d. Exploiting NMD vulnerability in spliceosome-mutant cancers

Major Contributions

a. Discovered a novel cytosolic DNA-elicited, Ca2+-mediated signaling pathway that safeguards DNA replication forks to preserve genome stability. (Mol Cell, 2019; Mol Cell 2023; Nat Commun, 2024)

b. Uncovered a novel interplay on the endoplasmic reticulum between the ion channel TRPV2 and the innate immune sensor STING, revealing a new mechanism for the co-regulation of Ca2+ dynamics and immune activation. (Mol Cell 2023; Cell Rep, accepted)

c. Pioneered the development of NMD reporter systems, enabling the identification of novel NMD inhibitors and genetic regulators, and demonstrated that NMD is modulated by intracellular Ca2+ and persistent DNA damage. (Nat Med 2014; JBC 2017)

d. Established NMD as a promising therapeutic target for cancers harboring spliceosome mutations. (Cancer Res 2021, Cancer Res, in review)

Representative Publications

Nature Communications, 2024, doi: 10.1038/s41467-024-48988-6. PMID: 38816425.

Molecular Cell, 2023, doi: 10.1016/j.molcel.2022.12.034. PMID: 36696898.

Molecular Cell, 2019, doi: 10.1016/j.molcel.2019.04.003. PMID: 31053472.

Cancer Research, 2021, doi: 10.1158/0008-5472.CAN-20-4016. PMID: 34215620.

Nature Medicine, 2014, doi: 10.1038/nm.3620. PMID: 25064126.

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Open Positions

Research Associate Investigator/

Research Assistant Investigator

Main Responsibilities

a. Conduct research independently under the guidance of the PI.

b. Assist in supervising graduate students and in writing research papers and grant proposals.

Qualifications

a. A Ph.D. in cell biology, bioinformatics, structural biology or related fields, with at least 3 years of postdoctoral research experience.

b. A strong publication record, evidenced by first-author publications in reputable journals.

c. Demonstrated ability to conduct independent research and mentor graduate students, with a strong passion for scientific research.

d. High proficiency in written and spoken English, with the ability to communicate effectively and prepare manuscripts.

Postdoctoral Researcher

Main Responsibilities

a. Conduct research projects independently under the guidance of the PI.

b. Assist in supervising graduate students and writing research papers and grant proposals.

Qualifications

a. A recent Ph.D. in cell biology, bioinformatics, structural biology or related fields.

b. Proven track record of first-author publications in reputable journals in the field.

c. Demonstrated ability to conduct independent research and mentor graduate students, with a strong passion for scientific research.

d. Proficiency in written and spoken English, with the ability to communicate effectively and prepare manuscripts.

Research Assistant

Main Responsibilities

a. Assist the team in conducting research projects.

b. Oversee the daily operation and maintenance of laboratory equipment, and assist the PI with lab management and administrative tasks.

Qualifications

a. Bachelor's degree or higher in molecular biology, cell biology, biochemistry or related disciplines.

b. Proactive work attitude with strong organizational skills and attention to detail.

c. Excellent communication skills and a collaborative team spirit.

d. Proficiency in English reading, writing, and daily communication.

Welfare Treatment

a. Competitive salary based on the applicant’s work experience and ability (salary negotiable).

b. Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c. Opportunities for career development and available professional guidance.

How to apply

To apply, please send a personal resume, research interest or plan, the names and contacts of 2-3 referees, and other materials demonstrating research capabilities to zyou@cimrbj.ac.cn and indicate the applicant's name and specific job position in the email subject.

Contact person: Prof. Zhongsheng You

This recruitment is valid for the long term until a suitable candidate is recruited.

Additionally, our laboratory welcomes interns and joint trainees at all stages who are interested in cellular immunotherapy to come and exchange ideas.

原文出处：

https://mp.weixin.qq.com/s/E-3MQYYaqRuBP8y_c6JpRQ